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KMID : 1139220180140010024
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Journal of Exercise Rehabilitation
2018 Volume.14 No. 1 p.24 ~ p.31
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Association of sericin and swimming on the phenotype, motor plate, and functionality of the denervated plantar muscle of Wistar rats
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Santana Andre
Debastiani Jean Carlos
Kunz Regina Ines
Buratti Pamela
Brancalhao Rose Meire Costa
De Fatima Chasko Ribeiro Lucineia
Torrejais Marcia Miranda
Bertolini Gladson Ricardo Flor
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Abstract
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Physical exercise may help maintain muscle properties and functional improvement after peripheral nerve lesion, which may be enhanced by using biocompatible substances, such as sericin. The aim of this study was analyse the effect of sericin associated with swimming exercise on the phenotype, innervation, and functionality of the plantar muscle of Wistar rats. Forty randomly divided adult rats were used in five groups of eight animals: control, injury, sericin, exercise, exercise and sericin. The application of sericin was done on the spot, 100 μL, shortly after nerve compression. Three days after sciatic nerve compression, the swimming and swimming and sericin groups were submitted to physical swimming exercise for 21 days. Afterwards, the animals were euthanised and the plantar muscle was dissected and submitted to histochemical and histoenzymological techniques. The grip strength test did not show alterations in muscular functionality, and the control presented greater muscle mass in relation to the other groups, the same did not occur for muscle length. Polymorphic neuromuscular junctions were detected in the groups, although without significant morphometric alterations of the area, major and minor diameters. The percentage of type I fibres was lower in the lesion group and there was no difference in fibres IIa and IIb between groups. The area of fibres I, IIa and IIb remained constant between groups. Sericin biopolymer combined with swimming exercise did not affect plantar muscle function, submitted to experimental axonotmosis, whose contractile properties were altered by nerve injury.
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KEYWORD
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Peripheral nerves, Muscle fibre, Physical exercise, Nerve injury, Silk protein
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